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Nrf2/NOX2 Pathway Dysregulation and Oxidative Stress Biomarkers in Gaucher Disease-Associated Parkinsonism: Insights Into a Potential Therapeutic Target

: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, yet its underlying genetic and molecular mechanisms remain incompletely understood. Variants in the GBA gene, encoding the lysosomal enzyme glucocerebrosidase, are not only responsible for Gaucher disease (GD) but also represent a significant genetic risk factor for PD, contributing to lysosomal dysfunction, oxidative stress and autophagy impairment. Among the key regulators of redox homeostasis, the Nrf2/NOX2...

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Higher levels of Monocyte Distribution Width as a potential flagging parameter of HIV progression: results of a monocentric observational study

Objectives: Monocyte Distribution Width (MDW) is the standard deviation of the mean volume of monocytes and may indicate innate immune activation. We investigated the possible association between MDW values and late HIV diagnosis in consecutive patients. Methods: We retrospectively enrolled newly diagnosed HIV patients admitted to our clinical center. Demographic and clinical characteristics were analyzed. Results: A total of 97 patients were enrolled. Of these, 63% were late presenters and 4...

FAIR foundations of a novel indicator vault for non-communicable diseases in the European Union: feasibility study for effective contextualisation of indicators

Background: Comparing health indicators across the European Union (EU) is a challenging endeavour. A feasibility study was conducted to explore opportunities for improvement through the contextualisation of indicators for major non-communicable diseases (NCDs). We aimed to improve the usability and transparency of indicators in the domain of NCDs by describing the contextual information about the data from which they draw and the related data processes. In particular, we sought to illustrate ...

Cardiovascular prevention begins in the classroom: Lessons from the CardioTOSchool study

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From “sliding” to “winding” filaments theory: A narrative review of mechanisms behind skeletal muscle contraction
QUADAS-3: updated tool to evaluate risk of bias and applicability concerns in diagnostic test accuracy studies [oral presentation]
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Upper arch dimensional changes with clear aligners in the early mixed dentition
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Functional outcomes of copy number variations of Chrna7 gene: current knowledge and new insight from induced pluripotent stem cells studies
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Exploring the role of dreams: insights from recent studies
Long-Term Assessment of Treatment Timing for Rapid Maxillary Expansion and Facemask Therapy Followed by Fixed Appliances: A Multicenter Retro-Prospective Study
Breed predispositions and malignancy analysis for canine tumors: A multicenter histopathological retrospective study from Central Italy
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The refusal of medical treatment by the parents of a minor and the prevention of recourse to the tutelary judge: The case of blood transfusion/ Il rifiuto del trattamento sanitario da parte dei genitori della persona minore di età e la prevenzione del ricorso al giudice tutelare: Il caso della trasfusione ematica
Empowering Nurses Through Data Literacy and Data Science Literacy: Insights from a State-of-the-Art Literature Review
Beyond the ‘purple drank’. Study of promethazine abuse according to the European Medicines Agency (EMA) Adverse Drug Reactions (ADR) reports

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Nrf2/NOX2 Pathway Dysregulation and Oxidative Stress Biomarkers in Gaucher Disease-Associated Parkinsonism: Insights Into a Potential Therapeutic Target

Gli strumenti della ricerca

Higher levels of Monocyte Distribution Width as a potential flagging parameter of HIV progression: results of a monocentric observational study

FAIR foundations of a novel indicator vault for non-communicable diseases in the European Union: feasibility study for effective contextualisation of indicators

Cardiovascular prevention begins in the classroom: Lessons from the CardioTOSchool study

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