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Prodotti recenti

SARS-CoV-2 Infection of Human Ovarian Cells: A Potential Negative Impact on Female Fertility

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect female reproductive health. Here, we investigated the potential of SARS-CoV-2 to infect the follicular microen-vironment, in particular granulosa (GCs) and cumulus cells (CCs), thus providing evidence for a productive infection. GCs and CCs were recovered from women (n = 25) who underwent in vitro fertilization at the Assisted Reproductive Unit, Siena University Hospital. Follicular ovarian cells were co-cultured with SAR...

Near Full-Length Sequence Analysis of HIV Type 1 BF Recombinants from Italy

Abstract Recombination between HIV-1 subtypes B and F has generated several circulating and unique recombinant forms, particularly in Latin American areas. In Italy, subtype B is highly prevalent while subtype F is the most common pure non-B subtype. To investigate the recombination pattern in Italian BF recombinant viruses, we characterized full-length sequences derived from 15 adult patients, mostly Italian and infected by the heterosexual route. One of the BF mosaics was a CRF29, three seq...

Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro

Sofosbuvir, a licensed nucleotide analog targeting hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), has been recently evaluated as a broad anti-Flavivirus lead candidate revealing activity against Zika and Dengue viruses both in vitro and in animal models. In this study, the in vitro antiviral activity of sofosbuvir against West Nile virus (WNV) was determined by plaque assay (PA) and Immunodetection Assay (IA) in human cell lines and by enzymatic RdRp assay. By PA, the sofosbuvir...

Hepatitis B virus vaccination in HIV-1-infected young adults: A tool to reduce the size of HIV-1 reservoirs?

During anti-retroviral therapy (ART) HIV-1 persists in cellular reservoirs, mostly represented by CD4+ memory T cells. Several approaches are currently being undertaken to develop a cure for HIV-1 infection through elimination (or reduction) of these reservoirs. Few studies have so far been conducted to assess the possibility of reducing the size of HIV-1 reservoirs through vaccination in virologically controlled HIV-1-infected children. We recently conducted a vaccination study with a combin...

Role of phenotypic investigation in the era of routine genotypic HIV-1 drug resistance testing

The emergence of drug resistance can seriously compromise HIV type-1 therapy and decrease therapeutic options. Resistance testing is highly recommended to guide treatment decisions and drug activity can be accurately predicted in the clinical setting through genotypic assays. While phenotypic systems are not suitable for monitoring drug resistance in routine laboratory practice, genotyping can misclassify unusual or complex mutational patterns, particularly with recently approved antivirals. ...

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  • INTERNATIONAL JOURNAL OF MOLECULA...148
  • EUROPEAN REVIEW FOR MEDICAL AND P...88
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  • PLOS ONE83
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  • PRACTICAL ISSUES IN GERIATRICS5
  • IQWIG-BERICHTE4
  • LECTURE NOTES IN COMPUTER SCIENCE3
  • ADVANCES IN EXPERIMENTAL MEDICINE...2
  • ITALIAN STATISTICAL SOCIETY SERIE...2
  • PHILOSOPHICA DIGITAL2
  • SIDREA SERIES IN ACCOUNTING AND B...2
  • ADVANCES IN EXPERIMENTAL MEDICINE...1
  • CURRENT TOPICS IN BEHAVIORAL NEUR...1
  • EDUCATORI ANTICHI E MODERNI1
Data di pubblicazione
  • In corso di stampa16
  • 2020 - 20254294
  • 2010 - 20194717
  • 2000 - 20091864
  • 1990 - 1999924
  • 1980 - 1989324
  • 1977 - 19792
Testo statico 2
Prodotti più visti
  • Upper arch dimensional changes with clear aligners in the early mixed dentition
  • Validation Study of Italian Version of Inventory for Deja Vu Experiences Assessment (I-IDEA): A Screening Tool to Detect Deja Vu Phenomenon in Italian Healthy Individuals
  • Lisdexamfetamine in the treatment of moderate-to-severe binge eating disorder in adults: Systematic review and exploratory meta-analysis of publicly available placebo-controlled, randomized clinical trials
  • High dose amoxicillin-based first line regimen is equivalent to sequential therapy in the eradication of H. pylori infection
  • Focal active colitis as a predictor of inflammatory bowel disease: results from a single-center experience
  • The role of intestinal microbiota and the immune system
  • The identification of biomarkers predicting acute and maintenance lithium treatment response in bipolar disorder: A plea for further research attention
  • Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy
  • Do aspartate and asparagine acute supplementation influence the onset of fatigue in intense exercise?
  • Results of an Observational Cohort Study of Hyperuricemia as a Predictor of Poor Physical Performance in the Elderly
Prodotti più scaricati
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  • Development and content validity of educational videos on self‐management of fluid restriction and thirst for individuals with heart failure
  • Functional outcomes of copy number variations of Chrna7 gene: current knowledge and new insight from induced pluripotent stem cells studies
  • Upper arch dimensional changes with clear aligners in the early mixed dentition
  • Exploring the role of dreams: insights from recent studies
  • Conventional versus laser gingivectomy in the management of gingival enlargement during orthodontic treatment: a randomized controlled trial
  • Evaluation of maxillary arch dimensions and palatal morphology in mouth-breathing children by using digital dental casts
  • Association between gambling disorder and emotion (dys)regulation: A systematic review and meta-analysis
  • Empowering Nurses Through Data Literacy and Data Science Literacy: Insights from a State-of-the-Art Literature Review
  • Patient blood management: The best approach to transfusion medicine risk management

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