Home page

Testo statico 1

Prodotti recenti

Urokinase receptor interacts with αvβ5 vitronectin receptor promoting urokinase-dependent cell migration in breast cancer

Perturbation of adhesive interactions at cell-substratum and cell-cell contact sites is a critical event in the multistep process of cancer invasion. Recent studies indicate that the urokinase receptor (uPAR) is associated in large molecular complexes with other molecules, such as integrins. To test the possibility that uPAR may physically and functionally interact with vitronectin (V(n)) receptors, we determined the expression level of uPAR, αvβ3, and αvβ5 V(n) receptors in 10 human breast c...

Inhibition of migration and invasion of carcinoma cells by urokinase-derived antagonists of αvβ5 integrin activation

We previously showed that, while binding to urokinase receptor (uPAR) through its growth factor domain (GFD, residues 1-49), urokinase (uPA) can engage αvβ5 integrin through an internal domain (CP, residues 132-158). This novel uPA/αvβ5 interaction promotes cytoskeletal rearrangements and directional cell migration (Franco et al., J Cell Sci 2006;119:3424-34). We nowshow that treatment of cells with phosphomimic uPA (uPA 138E/303E, serine 138 and 303 substituted with glutamic acid) strongly i...

An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity

We have recently described the purification and characterization of an insulin-degrading enzyme (IDE) from Drosophila melanogaster that can cleave porcine insulin, is highly conserved through evolution and is developmentally regulated. We now report that the IDE is, in fact, an insulin EGF-binding protein (dp100) that we had isolated previously from Drosophila using an antihuman EGF receptor antiserum. This conclusion is based upon the following evidence. (a) dp100, identified by its ability ...

Protein kinase C-dependent in vivo phosphorylation of prourokinase leads to the formation of a receptor competitive antagonist

We recently reported that in vivo phosphorylation of urokinase-type plasminogen activator on Ser(138/303) prevents its catalytic-independent ability to promote myelomonocytic cell adherence and motility. We now show that Ca2+ activated, phospholipid-dependent protein kinase C from rat brain phosphorylates in vitro a peptide corresponding to prourokinase residues 133- 143 (DGKKPSSPPEE) and the full-length molecule on Ser(138/139). The in vivo involvement of the protein kinase C isoenzyme famil...

Inhibiting monocyte recruitment to prevent the pro-tumoral activity of tumor-associated macrophages in chondrosarcoma

Chondrosarcomas (CHS) are malignant cartilaginous neoplasms with diverse morphological features, characterized by resistance to chemo- and radiation therapies. In this study, we investigated the role of tumor-associated macrophages (TAM)s in tumor tissues from CHS patients by immunohistochemistry. Three-dimensional organotypic co-cultures were set up in order to evaluate the contribution of primary human CHS cells in driving an M2-like phenotype in monocyte-derived primary macrophages, and th...

Ricerca

Aggiungi

Scopri

Testo statico 2

Prodotti più visti

Upper arch dimensional changes with clear aligners in the early mixed dentition
An Innovative Model of University Cooperation in Developing Countries: Results of 5 Years of Experience in Internal Medicine, Health Promotion and Education
Use of a new fixative for histiopathological studies based on methyl-ethylketone peroxide in order to eliminate the carcinogenic risk of formaldehyde
The need of leadership in managing healthcare and policy-making
Effects of pendulum appliance versus clear aligners in the vertical dimension during Class II malocclusion treatment: a randomized prospective clinical trial
Shared care plan: an extraordinary tool for the personalisation of medicine and respect for self-determination
"Occult" ovarian Leydig cell tumor: when laboratory tells more than imaging
'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease
50-Hz extremely low frequency electromagnetic fields (ELF-EMF) enhance cell proliferation and DNA damage: possible involvement of a redox mechanism
Ricerca sperimentale e processi valutativi in educazione

Prodotti più scaricati

Development and content validity of educational videos on self‐management of fluid restriction and thirst for individuals with heart failure
Functional outcomes of copy number variations of Chrna7 gene: current knowledge and new insight from induced pluripotent stem cells studies
Upper arch dimensional changes with clear aligners in the early mixed dentition
Conventional versus laser gingivectomy in the management of gingival enlargement during orthodontic treatment: a randomized controlled trial
Evaluation of maxillary arch dimensions and palatal morphology in mouth-breathing children by using digital dental casts
Characterization of Cell Death Pathways in Human Immunodeficiency Virus-Associated Encephalitis
Profiling complete regression after pre-operative therapy in gastric cancer patients using clinical and pathological data
A case report of a giant rectal adenoma causing secretory diarrhea and acute renal failure: McKittrick-Wheelock syndrome
Effects of pendulum appliance versus clear aligners in the vertical dimension during Class II malocclusion treatment: a randomized prospective clinical trial
Health and Economic Impact of Atrial Fibrillation of Workers in Italy: Social Security Benefits

Esplora il catalogo della ricerca

CINECA IRIS Institutial research information system

Prodotti recenti

Urokinase receptor interacts with αvβ5 vitronectin receptor promoting urokinase-dependent cell migration in breast cancer

Inhibition of migration and invasion of carcinoma cells by urokinase-derived antagonists of αvβ5 integrin activation

An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity

Protein kinase C-dependent in vivo phosphorylation of prourokinase leads to the formation of a receptor competitive antagonist

Inhibiting monocyte recruitment to prevent the pro-tumoral activity of tumor-associated macrophages in chondrosarcoma

Ricerca

Scopri

Tipologia

Rivista

Serie

Data di pubblicazione

Prodotti più visti

Prodotti più scaricati

11.101

pubblicazioni

537

open-access

5.097

downloads

1.720

fulltext

124

autori