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p27Kip1, an Intrinsically Unstructured Protein with Scaffold Properties

The Cyclin-dependent kinase (CDK) regulator p27Kip1 is a gatekeeper of G1/S transition. It also regulates G2/M progression and cytokinesis completion, via CDK-dependent or-independent mechanisms. Recently, other important p27Kip1 functions have been described, including the regulation of cell motility and migration, the control of cell differentiation program and the activation of apoptosis/autophagy. Several factors modulate p27Kip1 activities, including its level, cellular localization and ...

Effects of Magnetic Stimulation on Dental Implant Osseointegration: A Scoping Review

This PRISMA‐ScR driven scoping review aims to evaluate the influence of magnetic field stimulation on dental implant osseointegration. Seven databases were screened adopting ad‐hoc strings. All clinical and preclinical studies analyzing the effects of magnetic fields on dental implant osseointegration were included. From 3124 initial items, on the basis of the eligibility criteria, 33 articles, regarding both Pulsed ElectroMagnetic Fields (PEMF) and Static magnetic Fields from permanent Magne...

Pyrosequencing Evaluation of Low-Frequency KRAS Mutant Alleles for EGF Receptor Therapy Selection in Metastatic Colorectal Carcinoma

Aim: To evaluate whether pyrosequencing (PS) improves the KRAS mutational status predictive value. Patients & methods: A retrospective analysis of KRAS mutations by PS and direct sequencing (DS) in 192 metastatic colorectal carcinomas (mCRCs), subgrouped in 51 KRAS mutated at PS and 141 KRAS wild-type at DS. Results: DS failed to detect low-frequency KRAS mutations in four out of 51 mCRCs, whereas PS detected 12 additional low-frequency KRAS mutations in 141 mCRCs KRAS wild-type at DS. Af...

Histone Deacetylase Inhibitors Increase p27Kip1 by Affecting Its Ubiquitin‐Dependent Degradation through Skp2 Downregulation

Histone deacetylase inhibitors (HDACIs) represent an intriguing class of pharmacologically active compounds. Currently, some HDACIs are FDA approved for cancer therapy and many others are in clinical trials, showing important clinical activities at well tolerated doses. HDACIs also interfere with the aging process and are involved in the control of inflammation and oxidative stress. In vitro, HDACIs induce different cellular responses including growth arrest, differentiation, and apoptosis. H...

Iron overload enhances human mesenchymal stromal cell growth and hampers matrix calcification

Background Iron overload syndromes include a wide range of diseases frequently associated with increased morbidity and mortality. Several organs are affected in patients with iron overload including liver, heart, joints, endocrine glands, and pancreas. Moreover, severe bone and hemopoietic tissue alterations are observed. Because of the role of bone marrow mesenchymal stromal cells (BM-MSCs) in bone turnover and hematopoiesis, iron effects on primary BM-MSCs cultures were evaluated. Methods P...

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QUADAS-3: updated tool to evaluate risk of bias and applicability concerns in diagnostic test accuracy studies [oral presentation]
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Prodotti recenti

p27Kip1, an Intrinsically Unstructured Protein with Scaffold Properties

Effects of Magnetic Stimulation on Dental Implant Osseointegration: A Scoping Review

Pyrosequencing Evaluation of Low-Frequency KRAS Mutant Alleles for EGF Receptor Therapy Selection in Metastatic Colorectal Carcinoma

Histone Deacetylase Inhibitors Increase p27Kip1 by Affecting Its Ubiquitin‐Dependent Degradation through Skp2 Downregulation

Iron overload enhances human mesenchymal stromal cell growth and hampers matrix calcification

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