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Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells

Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support the idea that deregulated cellular metabolism is linked to such resistance. Indeed, both components of the glycolytic and mitochondrial pathways are involved in altered metabolism linked to chemoresistance of several cancers. Here we investigated the drug-induced metabolic adaptations able to confer advantages to docetaxel resistant prost...

Senescent stroma promotes prostate cancer progression: The role of miR-210

We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells, facili...

Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells

Huntington disease (HD) is a devastating and presently untreatable neurodegenerative disease characterized by progressively disabling motor and mental manifestations. The sigma-1 receptor (σ1R) is a protein expressed in the central nervous system, whose 3D structure has been recently determined by X-ray crystallography and whose agonists have been shown to have neuro-protective activity in neurodegenerative diseases. To identify therapeutic agents against HD, we have implemented a drug reposi...

Tracheal, bronchus, and lung cancer mortality and air pollution exposure in Tuscany, Italy: Bayesian Health Impact Assessment and Global Sensitivity Analysis on a sub-regional scale

: Outdoor air pollution is a significant risk factor for tracheal, bronchus, and lung (TBL) cancer. This study employs a Bayesian approach to evaluate TBL cancer mortality due to air pollution in Tuscany, Central Italy, in 2023. Using locally validated data, we assessed the impact of fine particulate matter (PM10 and PM2.5) and nitrogen dioxide (NO2) in terms of attributable deaths and years of life lost (YLL). Our three-step methodology included: (1) Bayesian modeling to derive posterior dis...

I° Corso di Implementazione e Perfezionamento: Preabilitazione, Enhanced Recovery After Surgery e Riabilitazione. L’importanza del team

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Shared care plan: an extraordinary tool for the personalisation of medicine and respect for self-determination
Effects of pendulum appliance versus clear aligners in the vertical dimension during Class II malocclusion treatment: a randomized prospective clinical trial
"Occult" ovarian Leydig cell tumor: when laboratory tells more than imaging
Upper arch dimensional changes with clear aligners in the early mixed dentition
'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease
50-Hz extremely low frequency electromagnetic fields (ELF-EMF) enhance cell proliferation and DNA damage: possible involvement of a redox mechanism
Placental Dysfunction in Assisted Reproductive Pregnancies: Perinatal, Neonatal and Adult Life Outcomes
A case report of a giant rectal adenoma causing secretory diarrhea and acute renal failure: McKittrick-Wheelock syndrome
Adverse effects of engineered nanomaterials: exposure, toxicology and impact on human health: Second Edition
Rapid maxillary expansion: Effects on palatal area investigated by computed tomography in growing subjects

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Evaluation of maxillary arch dimensions and palatal morphology in mouth-breathing children by using digital dental casts
Characterization of Cell Death Pathways in Human Immunodeficiency Virus-Associated Encephalitis
Conventional versus laser gingivectomy in the management of gingival enlargement during orthodontic treatment: a randomized controlled trial
Profiling complete regression after pre-operative therapy in gastric cancer patients using clinical and pathological data
A case report of a giant rectal adenoma causing secretory diarrhea and acute renal failure: McKittrick-Wheelock syndrome
The impact of preoperative nutritional screening, ERAS protocol, and mini-invasive surgery in surgical oncology: A multi-institutional SEM analysis of patients with digestive cancer
Evaluation of immunity for mumps among vaccinated medical students
Impact of COVID-19 on vascular patients worldwide: analysis of the COVIDSurg data
Effects of pendulum appliance versus clear aligners in the vertical dimension during Class II malocclusion treatment: a randomized prospective clinical trial
Health and Economic Impact of Atrial Fibrillation of Workers in Italy: Social Security Benefits

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Prodotti recenti

Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells

Senescent stroma promotes prostate cancer progression: The role of miR-210

Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells

Tracheal, bronchus, and lung cancer mortality and air pollution exposure in Tuscany, Italy: Bayesian Health Impact Assessment and Global Sensitivity Analysis on a sub-regional scale

I° Corso di Implementazione e Perfezionamento: Preabilitazione, Enhanced Recovery After Surgery e Riabilitazione. L’importanza del team

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