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HIF3A inhibition triggers browning of white adipocytes via metabolic rewiring

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Autophagy is a lysosome dependent cell survival mechanism and is central to the maintenance oforganismal homeostasis in both physiological and pathological situations. Targeting autophagy in cancertherapy attracted considerable attention in the past as stress-induced autophagy has been demonstratedto contribute to both drug resistance and malignant progression and recently interest in this area has re-emerged. Unlocking the therapeutic potential of autophagy modulation could be a valuable str...

A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin

Aberrant epigenetic modifications are involved in cancer development. Jumonji C domain-containing histone lysine demethylases (KDMs) are found mainly up-regulated in breast, prostate, and colon cancer. Currently, growing interest is focusing on the identification and development of new inhibitors able to block the activity of KDMs and thus reduce tumor progression. KDM4A is known to play a role in several cellular physiological processes, and was recently found overexpressed in a number of pa...

Structure-Based Discovery of Hsp90/HDAC6 Dual Inhibitors Targeting Aggressive Prostate Cancer

HDAC6 and Heat Shock Protein 90 (Hsp90) are key regulators within the androgen response pathway, exhibiting a close interplay and mutual interaction patterns that make their combined inhibition a promising strategy for treating aggressive prostate cancer (PC). Herein, we present the structure-based design of dual inhibitors of Hsp90 and HDAC6 that leveraged the crystal structure requirements of HDAC6 and two distinct Hsp90 binding pockets. The study led to the discovery of compound 17, a pote...

“Aging and epigenetic implications in radiotherapy: The promise of BNCT”

: Although cancer treatment strategies have made considerable progress in recent decades, the challenge of selectively killing tumor cells while minimizing damage to healthy tissue remains. Radiotherapy (RT) continues to be crucial for tumor growth control when combined with surgery, chemotherapy, and immunotherapy. RT effectiveness depends on factors such as cancer type, tumor features, and the choice of external or internal treatment. Given its non-invasive nature and low systemic toxicity,...

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La prescrizione infermieristica: quali prospettive in Italia?
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Exploring the role of dreams: insights from recent studies
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Breed predispositions and malignancy analysis for canine tumors: A multicenter histopathological retrospective study from Central Italy
Functional outcomes of copy number variations of Chrna7 gene: current knowledge and new insight from induced pluripotent stem cells studies
Dreaming for Two: A Systematic Review of Mental Sleep Activity during Pregnancy
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Beyond the ‘purple drank’. Study of promethazine abuse according to the European Medicines Agency (EMA) Adverse Drug Reactions (ADR) reports
Long-Term Assessment of Treatment Timing for Rapid Maxillary Expansion and Facemask Therapy Followed by Fixed Appliances: A Multicenter Retro-Prospective Study
Cognitive profile and brain morphological changes in obstructive sleep apnea
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Prodotti recenti

HIF3A inhibition triggers browning of white adipocytes via metabolic rewiring

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin

Structure-Based Discovery of Hsp90/HDAC6 Dual Inhibitors Targeting Aggressive Prostate Cancer

“Aging and epigenetic implications in radiotherapy: The promise of BNCT”

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