In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studieswas developed. Experience, anecdotal reports, and feedback suggested areas forimprovement; therefore, QUADAS-2 was developed. This tool comprises 4 domains:patient selection, index test, reference standard, and flow and timing. Eachdomain is assessed in terms of risk of bias, and the first 3 domains are alsoassessed in terms of concerns regarding applicability. Signalling questions areincluded to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases:summarize the review question, tailor the tool and produce review-specificguidance, construct a flow diagram for the primary study, and judge bias andapplicability. This tool will allow for more transparent rating of bias andapplicability of primary diagnostic accuracy studies.
QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies
Rutjes A;
2011-01-01
Abstract
In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studieswas developed. Experience, anecdotal reports, and feedback suggested areas forimprovement; therefore, QUADAS-2 was developed. This tool comprises 4 domains:patient selection, index test, reference standard, and flow and timing. Eachdomain is assessed in terms of risk of bias, and the first 3 domains are alsoassessed in terms of concerns regarding applicability. Signalling questions areincluded to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases:summarize the review question, tailor the tool and produce review-specificguidance, construct a flow diagram for the primary study, and judge bias andapplicability. This tool will allow for more transparent rating of bias andapplicability of primary diagnostic accuracy studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
