Re: Birth of 16 healthy children after ICSI in cases of nonmosaic klinefelter syndrome

Individuals with the nonmosaic form of Klinefelter syndrome are nearly always azoospermic. For these men testicular sperm extraction is typically the only way to obtain sperm. These investigators report that sperm was successfully surgically retrieved from the testes of 15 of 38 men with nonmosaic Klinefelter syndrome, resulting in 15 pregnancies and 16 live births following intracytoplasmic sperm injection. Karyotyping by amniocentesis and after birth revealed that all 16 patients had normal chromosomal complements. While the total number of births in this study is small, it is still one of the largest series of its kind, and it may bring some comfort to men undergoing testicular sperm extraction for nonmosaic Klinefelter syndrome to know that they are unlikely to pass the condition to their offspring.