Immunological mechanisms may contribute to the pathogenesis of some epileptic syndrome. This review provides some basic immunology to understand the scenario in which the hitherto reported immunological (mostly humoral) abnormalities of pts with epilepsy might play a role. The major evidences in favor of an immunological pathogenesis of epilepsy (hypogammaglobulinemia of epileptic patients, low IgA levels during PHT treatment, circulating CNS autoantibodies and HLA association of epileptic syndromes) are critically discussed. Tighter clinical selection criteria, more basic immunology studies in patients with epilepsy and new experimental models are needed to provide more than anedoctal evidence in favor of an immune-mediated pathogenesis of epilepsy.
The immunopathology of epilepsy | Basi immunopatologiche dell'epilessia
Grimaldi, Luigi Maria Edoardo
1994-01-01
Abstract
Immunological mechanisms may contribute to the pathogenesis of some epileptic syndrome. This review provides some basic immunology to understand the scenario in which the hitherto reported immunological (mostly humoral) abnormalities of pts with epilepsy might play a role. The major evidences in favor of an immunological pathogenesis of epilepsy (hypogammaglobulinemia of epileptic patients, low IgA levels during PHT treatment, circulating CNS autoantibodies and HLA association of epileptic syndromes) are critically discussed. Tighter clinical selection criteria, more basic immunology studies in patients with epilepsy and new experimental models are needed to provide more than anedoctal evidence in favor of an immune-mediated pathogenesis of epilepsy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
