Objective: The possible relevance of osteoarthritis (OA) as a cardiovascular disease (CVD) risk factor is still debated. We aimed to investigate the association between OA and the onset of CVD in older people. Methods: Among a sample of 3099 elderly subjects, we considered 2158 who had no CVD at the baseline and were followed for 4.4±1.2 years. OA was defined using a standardized algorithm investigating disease history, medical documentation (including X-ray reports), symptoms, and physical examination of the joints. Incident CVD was defined as the onset of coronary artery disease, heart failure, stroke/transient ischemic attack, peripheral artery disease, and CVD-related hospitalization or mortality. Results: At the baseline, 1336 participants (=61.9%) suffered from OA. Participants with OA had more potential CVD risk factors, including obesity, hypertension, high LDL and inflammation levels, and a worse renal function than those without. During the follow-up, 47.8% of the participants with OA at the baseline developed a new CVD vs. 41.3% of those without. Using an adjusted Cox's regression analysis, the presence of OA significantly increased the risk of CVD (HR=1.22, 95%CI: 1.02-1.49, p=0.04). The association between OA and CVD was stronger when the hip or knee were affected, in women, and when more than two joints were involved. Considering single CVD outcomes, the presence of OA significantly increased the risk of new coronary artery disease, heart failure, and hospitalization for CVD. Conclusions: OA significantly predicted the onset of CVD in elderly people, particularly when it involved lower limbs, women, and more than two joints. This article is protected by copyright. All rights reserved.
Osteoarthritis increases the risk of cardiovascular diseases in the elderly: The Progetto Veneto Anziano study
Veronese, Nicola;
2016-01-01
Abstract
Objective: The possible relevance of osteoarthritis (OA) as a cardiovascular disease (CVD) risk factor is still debated. We aimed to investigate the association between OA and the onset of CVD in older people. Methods: Among a sample of 3099 elderly subjects, we considered 2158 who had no CVD at the baseline and were followed for 4.4±1.2 years. OA was defined using a standardized algorithm investigating disease history, medical documentation (including X-ray reports), symptoms, and physical examination of the joints. Incident CVD was defined as the onset of coronary artery disease, heart failure, stroke/transient ischemic attack, peripheral artery disease, and CVD-related hospitalization or mortality. Results: At the baseline, 1336 participants (=61.9%) suffered from OA. Participants with OA had more potential CVD risk factors, including obesity, hypertension, high LDL and inflammation levels, and a worse renal function than those without. During the follow-up, 47.8% of the participants with OA at the baseline developed a new CVD vs. 41.3% of those without. Using an adjusted Cox's regression analysis, the presence of OA significantly increased the risk of CVD (HR=1.22, 95%CI: 1.02-1.49, p=0.04). The association between OA and CVD was stronger when the hip or knee were affected, in women, and when more than two joints were involved. Considering single CVD outcomes, the presence of OA significantly increased the risk of new coronary artery disease, heart failure, and hospitalization for CVD. Conclusions: OA significantly predicted the onset of CVD in elderly people, particularly when it involved lower limbs, women, and more than two joints. This article is protected by copyright. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
