Background: To investigate the presence of laryngopharyngeal reflux inpatients with obstructive sleep apnea (OSA) employing the salivary pepsinconcentration method. To compare the results of pepsin concentration with theseverity of the pathology. Methods: Seventy-five OSA patients (44 males, 31females) were enrolled in the study. For each patient, the AHI (apnea–hypopneaindex) and the BMI (body mass index) were initially evaluated. All the patientsenrolled were assessed using the reflux symptom index (RSI) and the reflux findingscore (RFS) in order to perform a clinical diagnosis of laryngopharyngeal reflux. Inall patients a salivary sample was taken to estimate the presence of pepsin and itsconcentration. Results: The incidence of LPR (laryngopharyngeal reflux) in OSApatients, evaluated using the salivary pepsin concentration test (PEP-test), wasfound to be 32% of cases. Linear regression testing did not show any correlationbetween AHI and pepsin concentration in salivary samples (p = 0.1). Conclusion: Ahigh number of patients with OSA seem to show positivity for salivary pepsin,correlated to an LPR. There does not appear to be a correlation between the severityof apnea and the grade of salivary pepsin reflux. On the other hand, direct correlation between BMI and the value of pepsin in salivary specimens wasobserved.
Laryngopharyngeal reflux diagnosis in obstructive sleep apnea patients using the pepsin salivary test
Annalisa Pace;
2019-01-01
Abstract
Background: To investigate the presence of laryngopharyngeal reflux inpatients with obstructive sleep apnea (OSA) employing the salivary pepsinconcentration method. To compare the results of pepsin concentration with theseverity of the pathology. Methods: Seventy-five OSA patients (44 males, 31females) were enrolled in the study. For each patient, the AHI (apnea–hypopneaindex) and the BMI (body mass index) were initially evaluated. All the patientsenrolled were assessed using the reflux symptom index (RSI) and the reflux findingscore (RFS) in order to perform a clinical diagnosis of laryngopharyngeal reflux. Inall patients a salivary sample was taken to estimate the presence of pepsin and itsconcentration. Results: The incidence of LPR (laryngopharyngeal reflux) in OSApatients, evaluated using the salivary pepsin concentration test (PEP-test), wasfound to be 32% of cases. Linear regression testing did not show any correlationbetween AHI and pepsin concentration in salivary samples (p = 0.1). Conclusion: Ahigh number of patients with OSA seem to show positivity for salivary pepsin,correlated to an LPR. There does not appear to be a correlation between the severityof apnea and the grade of salivary pepsin reflux. On the other hand, direct correlation between BMI and the value of pepsin in salivary specimens wasobserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
