Zepyros. A webserver to evaluate the shape complementarity of protein–protein interfaces

Motivation: Shape complementarity of molecular surfaces at the interfaces is a well-known characteristic of protein-protein binding regions, and it is critical in influencing the stability of the complex. Measuring such complementarity is of great importance for a number of theoretical and practical implications; however, only a limited number of tools are currently available to efficiently and rapidly assess it. Results: Here, we introduce Zepyros (ZErnike Polynomials analYsis of pROtein Shapes), a webserver for fast measurement of the shape complementarity between two molecular interfaces of a given protein-protein complex using structural information. Zepyros is implemented as a publicly available tool with a user-friendly interface.