Long noncoding RNAs (lncRNAs) are regarded as crucial regulators ofcellular processes in Eukaryotes. About 40% of currently characterizedlncRNAs are specifically expressed in central nervous system,where they are involved in critical neural functions. Consistently,lncRNA aberrant expression is associated to neurological disorders.We recently identified a novel human lncRNA, linc-NeD125,that is induced in response to neuronal differentiation stimulusboth in tumour cell lines and in embryonic stem cells. Notably,linc-Ned125 is significantly upregulated in a specific and stilllargely uncharacterized subgroup (Group 4) of Medulloblastoma(MB), the most common malignant paediatric brain tumour.Combining mechanistic and functional studies, we unveiled a novellncRNA-mediated miRNA sponge regulatory network, in which thecross-talk among linc-NeD125, microRNAs and four Group 4 MBdriver gene transcripts may significantly contribute to Group 4 MBcancerogenesis.
Linc-NeD125 establishes a ceRNA network in Group 4 Medulloblastoma
Evelina Miele;
2016-01-01
Abstract
Long noncoding RNAs (lncRNAs) are regarded as crucial regulators ofcellular processes in Eukaryotes. About 40% of currently characterizedlncRNAs are specifically expressed in central nervous system,where they are involved in critical neural functions. Consistently,lncRNA aberrant expression is associated to neurological disorders.We recently identified a novel human lncRNA, linc-NeD125,that is induced in response to neuronal differentiation stimulusboth in tumour cell lines and in embryonic stem cells. Notably,linc-Ned125 is significantly upregulated in a specific and stilllargely uncharacterized subgroup (Group 4) of Medulloblastoma(MB), the most common malignant paediatric brain tumour.Combining mechanistic and functional studies, we unveiled a novellncRNA-mediated miRNA sponge regulatory network, in which thecross-talk among linc-NeD125, microRNAs and four Group 4 MBdriver gene transcripts may significantly contribute to Group 4 MBcancerogenesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
