Previous studies have shown that rats trained to self-administer heroin and cocaine exhibit opposite preferences, as a function of setting, when tested in a choice paradigm. Rats tested at home prefer heroin to cocaine, whereas rats tested outside the home prefer cocaine to heroin. Here, we investigated whether drug history would influence subsequent drug preference in distinct settings. Based on a theoretical model of drug-setting interaction, we predicted that regardless of drug history rats would prefer heroin at home and cocaine outside the home.

Heroin versus cocaine: opposite choice as a function of context but not of drug history in the rat

Meringolo, Maria;
2019-01-01

Abstract

Previous studies have shown that rats trained to self-administer heroin and cocaine exhibit opposite preferences, as a function of setting, when tested in a choice paradigm. Rats tested at home prefer heroin to cocaine, whereas rats tested outside the home prefer cocaine to heroin. Here, we investigated whether drug history would influence subsequent drug preference in distinct settings. Based on a theoretical model of drug-setting interaction, we predicted that regardless of drug history rats would prefer heroin at home and cocaine outside the home.
2019
context
drug abuse
drug addiction
drug choice
drug dependence
environment
opiates
opioids
psychostimulants
self-administration
analgesics
opioid
animals
choice behavior
cocaine
conditioning
classical
dopamine uptake inhibitors
heroin
male
rats
rats
sprague-dawley
self administration
environment
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14245/3666
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