Insights from human sleep research on neural mechanisms of Alzheimer’s disease

The current research in the field of sleep and AD is increasing in importance, denoting a possible innovative future in terms of non-invasive and early interventions and prevention strategies. The above-mentioned results on sleep electroencephalogram in relation with AD have to be considered as preliminary reports, because other confirmations are needed. Future researches should propose complex and integrated experimental protocols, in order to provide concurrent electrophysiological, behavioral, anatomical and neuropsychological data. At this purpose, longitudinal studies that follow the entire course of the pathology, since the preclinical stage of the disease are needed. Further investigations on the role of specific NREM sleep components are also required, with the aim of confirming the original and promising existing evidence.