Many in vitro studies demonstrated that metal oxide nanoparticles like zinc oxide and titanium dioxide are versatile platforms for industrial and biomedical applications. In this paper, investigation of the embryotoxic potential of these nanoparticles using the Embryonic stem Cells Test (EST) was evaluated. The EST is a validated in vitro toxicity test used to predict embryotoxicity of soluble chemical compounds, which only recently has been applied to nanoparticles, demonstrating its suitability also in nanotoxicology. Through such test, we were able to classify zinc oxide nanoparticles as not embryotoxic, while titanium dioxide nanoparticles appeared to be weakly embryotoxic.
A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test
Massimiani, Micol;Pietroiusti, Antonio;
2013-01-01
Abstract
Many in vitro studies demonstrated that metal oxide nanoparticles like zinc oxide and titanium dioxide are versatile platforms for industrial and biomedical applications. In this paper, investigation of the embryotoxic potential of these nanoparticles using the Embryonic stem Cells Test (EST) was evaluated. The EST is a validated in vitro toxicity test used to predict embryotoxicity of soluble chemical compounds, which only recently has been applied to nanoparticles, demonstrating its suitability also in nanotoxicology. Through such test, we were able to classify zinc oxide nanoparticles as not embryotoxic, while titanium dioxide nanoparticles appeared to be weakly embryotoxic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
