Malaria is an infection caused by the protozoan Plasmodium, transmitted to humans by Anopheles mosquitos. The diagnosis involves a combination of clinical observations, clinical history, and microscopic blood examination. In this study, we assessed Plasmodium falciparum infection in two patients of african origin with malaria diagnosis, using two different microscopic examination and hematological analyzers. The Sysmex XN-9000 is able of revealing, by the white cell differential (WDF) scattergram panel, an abnormal cluster indicative of the accumulation of plasmodium infected red blood cells, associated with a specific alarm signal on the Q-FLAG panel. The Mindray BC-6800 Plus also showed an anomalous cell cluster, linked to parasitized red blood cells in the differentiation channel (DIFF). Also in this case the cluster was associated with a specific alarm of ‘Infected red blood cells’ (‘InR’), identifying the number and percentage of infected red blood cells. Microscopic analysis confirmed the presence of ring forms of the parasite in both cases. Both XN-9000 and BC-6800 Plus, which integrate cytofluorimetric and cytomorphological analysis, demonstrated the potential for rapid and accurate diagnosis of malaria infection.
Two cases of Plasmodium falciparum malaria analyzed on Sysmex Xn-9000 and Mindray Bc-6800 Plus
Nicolai, Eleonora;
2024-01-01
Abstract
Malaria is an infection caused by the protozoan Plasmodium, transmitted to humans by Anopheles mosquitos. The diagnosis involves a combination of clinical observations, clinical history, and microscopic blood examination. In this study, we assessed Plasmodium falciparum infection in two patients of african origin with malaria diagnosis, using two different microscopic examination and hematological analyzers. The Sysmex XN-9000 is able of revealing, by the white cell differential (WDF) scattergram panel, an abnormal cluster indicative of the accumulation of plasmodium infected red blood cells, associated with a specific alarm signal on the Q-FLAG panel. The Mindray BC-6800 Plus also showed an anomalous cell cluster, linked to parasitized red blood cells in the differentiation channel (DIFF). Also in this case the cluster was associated with a specific alarm of ‘Infected red blood cells’ (‘InR’), identifying the number and percentage of infected red blood cells. Microscopic analysis confirmed the presence of ring forms of the parasite in both cases. Both XN-9000 and BC-6800 Plus, which integrate cytofluorimetric and cytomorphological analysis, demonstrated the potential for rapid and accurate diagnosis of malaria infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
