Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.
A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
Milanese, Chiara;
2020-01-01
Abstract
Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.File in questo prodotto:
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A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance.pdf
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