Plasma NGS can track the clonal evolution of EGFR-mutated NSCLCs. • C797S mutation is one of the most common mechanisms of acquired resistance to osimertinib. • First generation can target C797S mutants, albeit responses are usually transient. • Novel therapeutic strategies are eagerly awaited for overcoming C797S mutation. © 2023
Tracking Clonal Evolution of EGFR-Mutated Non-Small Cell Lung Cancer Through Liquid Biopsy: Management of C797S Acquired Mutation
Del Re, Marzia;
2023-01-01
Abstract
Plasma NGS can track the clonal evolution of EGFR-mutated NSCLCs. • C797S mutation is one of the most common mechanisms of acquired resistance to osimertinib. • First generation can target C797S mutants, albeit responses are usually transient. • Novel therapeutic strategies are eagerly awaited for overcoming C797S mutation. © 2023File in questo prodotto:
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