The synthesis of a novel microemulsion system composed of a fluorinated oil C8F17-CH2-CH—CH-C4H9 with a biocompatible hydrogenated surfactant, Montanox 80, is described. Investigation of the solubility of oxygen in these microe-mulsions showed that they absorbed more oxygen than Fluosol-DA, currently used as an oxygen transporter in biological systems. Oxygen absorption was comparable to that of blood. Light scattering studies showed that these systems are composed of small-sized aggregates which should, in principle, be compatible with blood. The toxicity of the oil C8F17CH2-CH»CH-was tested after intraperitoneal injection in rats. No toxic effects were observed at doses up to 5 g/kg. This study opens new perspectives for the development of oxygen-transporting compounds for biomedical applications. © 1990, Taylor & Francis Group, LLC. All rights reserved.
A new formulation for blood substitutes
Novelli, Antonio;
1990-01-01
Abstract
The synthesis of a novel microemulsion system composed of a fluorinated oil C8F17-CH2-CH—CH-C4H9 with a biocompatible hydrogenated surfactant, Montanox 80, is described. Investigation of the solubility of oxygen in these microe-mulsions showed that they absorbed more oxygen than Fluosol-DA, currently used as an oxygen transporter in biological systems. Oxygen absorption was comparable to that of blood. Light scattering studies showed that these systems are composed of small-sized aggregates which should, in principle, be compatible with blood. The toxicity of the oil C8F17CH2-CH»CH-was tested after intraperitoneal injection in rats. No toxic effects were observed at doses up to 5 g/kg. This study opens new perspectives for the development of oxygen-transporting compounds for biomedical applications. © 1990, Taylor & Francis Group, LLC. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
